La oficina de Relaciones Internacionales se permite transmitir la siguiente información de Beca ofrecida por la Universidad de Amsterdam, Holanda.
Ph.D. Student Position in Immunology
Academic Medical Center (AMC), University of Amsterdam, The Netherlands
At the Department of Cell Biology & Histology, the research group of Dr. Björn Clausen, which is embedded in the laboratory of Prof. Martien Kapsenberg, works on the characterization of Langerhans cell (LC) and dendritic cell (DC) function and development by different LC- and DC-specific gene targeting approaches.
Background: DC are professional antigen presenting cells specialized to induce and regulate T cell immunity and tolerance. LC are the resident DC population in skin epidermis where they form a contiguous network to detect any invading pathogen or antigen. Underlying the epidermis, the skin contains a second DC population, dermal DC, which are phenotypically, and may be functionally, distinct from LC. To determine the role(s) of these two skin DC subsets in the initiation and control of cutaneous (auto-)immunity and allergy, we have recently generated Langerin-DTR mice in which we achieve the specific and inducible in vivo depletion of LC, but not dermal DC (Bennett et al, J Cell Biol. 2005; 169:569).
Project: This PhD thesis will make use of the Langerin-DTR mouse model to study LC development and function in the steady state and explore their relative importance compared with dermal DC in orchestrating skin immunity and tolerance, including allergic contact hypersensitivity, cutaneous Leishmaniasis, graft-versus-host disease (GvHD) and UV-B induced immune suppression. To this aim, we offer a young team of researchers within a stimulating and collaborative research environment, unique tools (Langerin-DTR mice) and state-of-the-art equipment and facilities to address hitherto unresolved and important questions in LC/DC biology. In particular, FACS sorters as well as fluorescence, confocal and live video imaging microscopes are available within our department.
Applications: Enthusiastic candidates interested in this project should have a Masters degree in Science (M.Sc.) or equivalent, and a solid background in cellular and molecular biology.
Previous training in immunology, particularly in the mouse, would represent an advantage. Please send CV and 2 names of reference latest by September 15, 2005, to: Dr. Björn Clausen, Department of Cell Biology & Histology, Academic Medical Center (AMC), University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Para solicitar información adicional pueden contactar al Dr. Bjoern Clausen al correo electrónico b.e.clausen@amc.uva.nl Dept Cell Biology and Histology, Academic Medical. Center, University of Amsterdam.